GeneID: 167
Names
| Common Name: | AGT | Type: | Gene |
|---|---|---|---|
| Chromosome: | 1 (NC_000001.11) | Locus: | NG_008836.1 (AGT) |
| HUGO Symbol: | AGT | Full Name: | angiotensinogen |
| Exons: | 5 | Introns: | 4 |
Description:
The AGT gene encodes the plasma protein angiotensinogen, which serves as the precursor of angiotensin, a peptide hormone involved in the regulation of blood pressure, body fluid and electrolyte homeostasis. Angiotensinogen is mainly synthesized by the liver and is the only known substrate of renin, a protease secreted by the juxtaglomerular cells of the kidney. Its production can be enhanced by angiotensin II in a positive feedback loop, as well as plasma corticosteroid, estrogen and thyroxine hormone levels. Polymorphisms in this gene associated with risk of stroke in individuals with sickle cell disease.
Synonyms: ANHU , SERPINA8
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Weir MR, Dzau VJ, The renin-angiotensin-aldosterone system: a specific target for hypertension management., Am. J. Hypertens. , 12(12), 205S-213S, 1999
- Tang DC, Prauner R, Liu W, Kim KH, Hirsch RP, Driscoll MC, Rodgers GP, Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study., Am. J. Hematol. , 68(3), 164-9, 2001