GeneID: 163



Names

Common Name: ADORA2B Type: Gene
Chromosome: 17 (NC_000017.11) Locus: N/A
HUGO Symbol: ADORA2B Full Name: adenosine A2b receptor
Exons: 2 Introns: 1

Description:
ADORA2B encodes an adenosine receptor that belongs to the G protein-coupled receptor superfamily. Adenosine is a purine nucleoside produced by the catabolism of S-adenosylhomocysteine (SAH) and adenosine monophosphate (AMP) molecules. It is a ubiquitous signalling molecule with essential functions across all organ systems. Under conditions of stress, such as hypoxia or ischemia, the intracellular concentration of adenosine increases. ADORA2B requires higher than the physiologic concentration of adenosine for activation. Downstream effects of ADORA2B signalling include tissue adaptation to injury, increased ischaemia tolerance and attenuation of acute inflammation. Also, ADORA2B interacts with netrin-1, a neuronal guidance molecule, to dampen inflammatory cell accumulation during hypoxia. Notably, the persistence of adenosine signalling has been shown to result in excessive inflammatory tissue damage and in the development of severe diseases, such as acute lung, liver or kidney injury. Polymorphisms in this gene associated with pulmonary hypertension risk in sickle cell disease patients.

Synonyms: N/A

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Aherne CM, Kewley EM, Eltzschig HK, The resurgence of A2B adenosine receptor signaling., Biochim. Biophys. Acta , 1808(5), 1329-39, 2011 PubMed
  2. Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JG, Machado RF, A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease., Am. J. Respir. Crit. Care Med. , 186(4), 359-68, 2012 PubMed
  3. Chen JF, Eltzschig HK, Fredholm BB, Adenosine receptors as drug targets--what are the challenges?, Nat Rev Drug Discov , 12(4), 265-86, 2013 PubMed
Created on 2016-07-20 14:14:06, Last reviewed on 2016-08-02 00:41:22 (Show full history)


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