GeneID: 163


Common Name: ADORA2B Type: Gene
Chromosome: 17 (NC_000017.11) Locus: N/A
HUGO Symbol: ADORA2B Full Name: adenosine A2b receptor
Exons: 2 Introns: 1

ADORA2B encodes an adenosine receptor that belongs to the G protein-coupled receptor superfamily. Adenosine is a purine nucleoside produced by the catabolism of S-adenosylhomocysteine (SAH) and adenosine monophosphate (AMP) molecules. It is a ubiquitous signalling molecule with essential functions across all organ systems. Under conditions of stress, such as hypoxia or ischemia, the intracellular concentration of adenosine increases. ADORA2B requires higher than the physiologic concentration of adenosine for activation. Downstream effects of ADORA2B signalling include tissue adaptation to injury, increased ischaemia tolerance and attenuation of acute inflammation. Also, ADORA2B interacts with netrin-1, a neuronal guidance molecule, to dampen inflammatory cell accumulation during hypoxia. Notably, the persistence of adenosine signalling has been shown to result in excessive inflammatory tissue damage and in the development of severe diseases, such as acute lung, liver or kidney injury. Polymorphisms in this gene associated with pulmonary hypertension risk in sickle cell disease patients.

Synonyms: N/A


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Aherne CM, Kewley EM, Eltzschig HK, The resurgence of A2B adenosine receptor signaling., Biochim. Biophys. Acta , 1808(5), 1329-39, 2011 PubMed
  2. Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JG, Machado RF, A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease., Am. J. Respir. Crit. Care Med. , 186(4), 359-68, 2012 PubMed
  3. Chen JF, Eltzschig HK, Fredholm BB, Adenosine receptors as drug targets--what are the challenges?, Nat Rev Drug Discov , 12(4), 265-86, 2013 PubMed
Created on 2016-07-20 14:14:06, Last reviewed on 2016-08-02 00:41:22 (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.