GeneID: 162
Names
| Common Name: | PON1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 7 (NC_000007.14) | Locus: | NG_008779.1 (PON1) |
| HUGO Symbol: | PON1 | Full Name: | paraoxonase 1 |
| Exons: | 9 | Introns: | 8 |
Description:
The encoded protein belongs to the family of human serum paraoxonases, which are involved in the hydrolysis of a wide range of organophosphorous compounds, including paraoxon, neurotoxins and insecticides. It exhibits antioxidant properties in lipid metabolism via the removal of the biologically active products of lipid peroxidation (oxidative damage of lipids). It also exhibits antiatherogenic properties as PON1 deficiency in mice was shown to enhance lipoprotein oxidation and atherosclerosis development. Polymorphisms in this gene associated with risk for stroke in individuals with sickle cell disease.
Synonyms: ESA , PON , MVCD5 , arylesterase 1 , esterase A
Comments:
N/A
Number of entries/variants: 1
Publications / Origin
- Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ, Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis., Nature , 394(6690), 284-7, 1998
- Sorenson RC, Bisgaier CL, Aviram M, Hsu C, Billecke S, La Du BN, Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity., Arterioscler. Thromb. Vasc. Biol. , 19(9), 2214-25, 1999
- Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN, Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities., J. Lipid Res. , 46(6), 1239-47, 2005
- Flanagan JM, Sheehan V, Linder H, Howard TA, Wang YD, Hoppe CC, Aygun B, Adams RJ, Neale GA, Ware RE, Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia., Blood , 121(16), 3237-45, 2013