GeneID: 151


Common Name: APOL1-MYH9 Type: Intergenic Region
Chromosome: 22 (NC_000022.11) Locus: N/A
HUGO Symbol: N/A Full Name: N/A
Exons: N/A Introns: N/A

The APOL1 gene belongs to the apolipoprotein L family, which consists of six members located in close proximity to each other on chromosome 22. It is a lipid-binding protein involved in reverse cholesterol transport and plays a key role in innate immunity by conferring protection against Trypanosoma brucei infection. Several different transcript variants encoding different isoforms have been found for this gene. The MYH9 gene, located on chromosome 22, encodes a conventional non-muscle myosin that is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. A polymorphism in the APOL1-MYH9 intergenic region was shown to influence HbF levels in the general population of Sardinia.

Synonyms: N/A


External Links

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Sequence Viewer

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Publications / Origin

  1. Pays E, Vanhollebeke B, Mutual self-defence: the trypanolytic factor story., Microbes Infect. , 10(9), 985-9, 2008 PubMed
  2. Betapudi V, Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading., PLoS ONE , 5(1), e8560, 2010 PubMed
  3. Genovese G, Tonna SJ, Knob AU, Appel GB, Katz A, Bernhardy AJ, Needham AW, Lazarus R, Pollak MR, A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9., Kidney Int. , 78(7), 698-704, 2010 PubMed
Created on 2016-05-19 15:18:12, Last reviewed on (Show full history)

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