GeneID: 150


Names

Common Name: APOL4-APOL2 Type: Intergenic Region
Chromosome: 22 (NC_000022.11) Locus: N/A
HUGO Symbol: N/A Full Name: N/A
Exons: N/A Introns: N/A

Description:
Apolipoproteins of the L family (APOL) are lipid-binding proteins involved in lipid transport and metabolism. Lipids are important in several cellular processes, such as modulation of gene transcription and signal transduction (steroid hormones, second messengers and membrane function). Some APOL members are also implicated in host innate immunity with an important role in autophagy and apoptosis. The APOL gene family consists of six members located in close proximity to each other on chromosome 22. Altered expression of APOL2 and APOL4 genes associated with symptoms of schizophrenia. A polymorphism in the APOL4-APOL2 intergenic region was shown to influence HbF levels in the general population of Sardinia.

Synonyms: N/A

Comments:
N/A

External Links

No available links

Publications / Origin

  1. Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S, Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22., Proc. Natl. Acad. Sci. U.S.A. , 99(7), 4680-5, 2002
  2. Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A, Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia., Proc. Natl. Acad. Sci. U.S.A. , 105(5), 1620-5, 2008
  3. Galindo-Moreno J, Iurlaro R, El Mjiyad N, Díez-Pérez J, Gabaldón T, Muñoz-Pinedo C, Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein., Cell Death Dis , 5(0), e1275, 2014
Created on 2016-05-19 14:43:33, Last reviewed on 2016-05-19 14:45:36 (Show full history)


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