GeneID: 146


Common Name: IFNL3 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NG_042193.1 (IFNL3)
HUGO Symbol: IFNL3 Full Name: interferon, lambda 3
Exons: 5 Introns: 4

The encoded protein is a member of the type III interferon (IFN) family, whose genes are clustered together on chromosome 19. Type III IFNs bind to a distinct class II cytokine receptor, the IFNλ receptor complex (IFNλR) that consists of a unique ligand-binding chain (IFNλRα) and an accesory chain (IL10Rβ) shared with cytokines of the IL10 family. IFNλR is restricted to epithelial cells and hepatocytes. Binding of the IFNλR activates the JAK-STAT signalling pathway and induces expression of IFN-stimulated genes, leading to an antiviral response. Polymorphisms in this gene associated with viral clearance prediction in β-thalassaemia patients.

Synonyms: IL28B , IL28C , IL-28B


Publications / Origin

  1. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M, Genetic variation in IL28B and spontaneous clearance of hepatitis C virus., Nature , 461(7265), 798-801, 2009
  2. Odendall C, Kagan JC, The unique regulation and functions of type III interferons in antiviral immunity., Curr Opin Virol , 12(0), 47-52, 2015
  3. Origa R, Marceddu G, Danjou F, Perseu L, Satta S, Demartis FR, Piga A, Longo F, Lai ME, Vacquer S, Galanello R, IFNL3 polymorphisms and HCV infection in patients with beta thalassemia., Ann Hepatol , 14(3), 389-95, 2015
  4. Galani IE, Koltsida O, Andreakos E, Type III interferons (IFNs): Emerging Master Regulators of Immunity., Adv. Exp. Med. Biol. , 850(0), 1-15, 2015
Created on 2016-05-06 15:06:34, Last reviewed on (Show full history)

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