GeneID: 143


Names

Common Name: CSF2 Type: Gene
Chromosome: 5 (NC_000005.10) Locus: NG_033024.1 (CSF2)
HUGO Symbol: CSF2 Full Name: colony stimulating factor 2
Exons: 4 Introns: 3

Description:
The encoded protein belongs to the family of colony-stimulating factors (CSFs) that play pivotal roles in the survival, proliferation and differentiation of haematopoietic progenitors. The active form of the protein is found extracellularly as a homodimer. It exerts a broader effect on multiple cell lineages, especially macrophages and eosinophils, and acts directly on mature neutrophils to promote their antimicrobial activity. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Polymorphisms in this gene associated with stroke in sickle cell patients.

Synonyms: GM-CSF , GMCSF , colony stimulating factor 2 (granulocyte-macrophage)

Comments:
N/A

Number of entries/variants: 1

IthaScore

Publications / Origin

  1. Gasson JC, Molecular physiology of granulocyte-macrophage colony-stimulating factor., Blood , 77(6), 1131-45, 1991
  2. Root RK, Dale DC, Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients., J. Infect. Dis. , 179(0), S342-52, 1999
  3. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005
Created on 2016-05-04 17:03:26, Last reviewed on 2016-05-04 17:04:32 (Show full history)


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