GeneID: 132


Common Name: PLA2G4D-PLA2G4F Type: Intergenic Region
Chromosome: 15 (NC_000015.10) Locus: N/A
HUGO Symbol: PLA2G4D-PLA2G4F Full Name: N/A
Exons: N/A Introns: N/A

PLA2G4D and PLA2G4F belong to the family of cytosolic phospholipase A2 (cPLA2) enzymes, which catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids in the plasma membrane to produce free fatty acids and lysophospholipids. The cPLA2 enzymes consist of a Ca2+-dependent lipid binding domain and a catalytic α/β hydrolase domain. They are regulated through phosphorylation by mitogen-activated protein kinases. They are involved in various cellular processes, such as hemodynamic regulation and inflammatory response. Polymorphisms in this intergenic region (PLA2G4D-PLA2G4F) associated with HbF levels in sickle cell patients.

Synonyms: N/A


External Links

No available links

Publications / Origin

  1. Ohto T, Uozumi N, Hirabayashi T, Shimizu T, Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}., J. Biol. Chem. , 280(26), 24576-83, 2005
  2. Burke JE, Dennis EA, Phospholipase A2 structure/function, mechanism, and signaling., J. Lipid Res. , 50(0), S237-42, 2009
  3. Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016
Created on 2016-04-27 16:32:49, Last reviewed on (Show full history)

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