GeneID: 132


Names

Common Name: PLA2G4D-PLA2G4F Type: Intergenic Region
Chromosome: 15 (NC_000015.10) Locus: N/A
HUGO Symbol: PLA2G4D-PLA2G4F Full Name: N/A
Exons: N/A Introns: N/A

Description:
PLA2G4D and PLA2G4F belong to the family of cytosolic phospholipase A2 (cPLA2) enzymes, which catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids in the plasma membrane to produce free fatty acids and lysophospholipids. The cPLA2 enzymes consist of a Ca2+-dependent lipid binding domain and a catalytic α/β hydrolase domain. They are regulated through phosphorylation by mitogen-activated protein kinases. They are involved in various cellular processes, such as hemodynamic regulation and inflammatory response. Polymorphisms in this intergenic region (PLA2G4D-PLA2G4F) associated with HbF levels in sickle cell patients.

Synonyms: N/A

Comments:
N/A

External Links

No available links

Publications / Origin

  1. Ohto T, Uozumi N, Hirabayashi T, Shimizu T, Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}., J. Biol. Chem. , 280(26), 24576-83, 2005
  2. Burke JE, Dennis EA, Phospholipase A2 structure/function, mechanism, and signaling., J. Lipid Res. , 50(0), S237-42, 2009
  3. Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016
Created on 2016-04-27 16:32:49, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.