GeneID: 115


Common Name: ERG Type: Gene
Chromosome: 21 (NC_000021.9) Locus: NG_029732.1 (ERG)
HUGO Symbol: ERG Full Name: v-ets avian erythroblastosis virus E26 oncogene homolog
Exons: 12 Introns: 11

The encoded protein is a member of the ETS [erythroblast transformation-specific] family of regulatory transcription factors. The name of the family was derived from the avian erythroblastosis virus, E26, that carries the v-ets oncogene. Members of this family contain a conserved DNA-binding 'ETS' domain, a winged helix-turn-helix structure, that binds to sequences with a central GGA motif, and function as key regulators in diverse biological processes, including embryonic development, cell proliferation, differentiation, migration, apoptosis, cell cycle control, angiogenesis and inflammation. The ETS-domain proteins are also involved in malignancies. The inclusion of the ERG gene in chromosomal translocations results in oncogenic fusion gene products, such as EWS-ERG in Ewing's sarcoma, TMPSSR2-ERG and NDRG1-ERG in prostate cancer, and FUS-ERG in acute myeloid leukemia. Several transcript variants generated from combinatorial usage of three alternate promoters and complex splicing events have been reported, but the full-length nature of many of these variants has not been determined. Polymorphisms in this gene associated with avascular necrosis and stroke in sickle cell patients.

Synonyms: p55 , erg-3


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Publications / Origin

  1. Sharrocks AD, The ETS-domain transcription factor family., Nat. Rev. Mol. Cell Biol. , 2(11), 827-37, 2001 PubMed
  2. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH, Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis., Blood , 106(1), 372-5, 2005 PubMed
  3. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH, Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia., Nat. Genet. , 37(4), 435-40, 2005 PubMed
  4. Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE, Genetic predictors for stroke in children with sickle cell anemia., Blood , 117(24), 6681-4, 2011 PubMed
Created on 2016-04-27 14:30:47, Last reviewed on 2016-04-27 14:36:41 (Show full history)

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