GeneID: 114



Names

Common Name: VCAM1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_023034.2 (VCAM1)
HUGO Symbol: VCAM1 Full Name: vascular cell adhesion molecule 1
Exons: 9 Introns: 8

Description:
VCAM1 is a surface membrane glycoprotein that belongs to the immunoglobulin-like family. It functions as an adhesion molecule receptor expressed on vascular endothelial cells after stimulation by inflammatory cytokines, such as IL-1β and TNF-α. It mediates the recruitment of immune cells, such as lymphocytes and monocytes, and allows their transgression through the endothelial cell wall at sites of vascular injury. VCAM1 also functions as an important component of inflammatory signalling pathways, including MAPK and NF-κB. The upregulation of VCAM1 expression has been linked to inflammatory diseases, including artherosclerosis and rheumatoid arthritis. Polymorphisms in this gene associated with stroke in sickle cell patients. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.

Synonyms: CD106 , INCAM-100

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Taylor JG, Tang DC, Savage SA, Leitman SF, Heller SI, Serjeant GR, Rodgers GP, Chanock SJ, Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease., Blood , 100(13), 4303-9, 2002 PubMed
  2. Kutlar A, Sickle cell disease: a multigenic perspective of a single gene disorder., Hemoglobin , 31(2), 209-24, 2007 PubMed
Created on 2016-04-27 12:57:54, Last reviewed on 2016-04-27 12:59:01 (Show full history)


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