GeneID: 114


Common Name: VCAM1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_023034.2 (VCAM1)
HUGO Symbol: VCAM1 Full Name: vascular cell adhesion molecule 1
Exons: 9 Introns: 8

VCAM1 is a surface membrane glycoprotein that belongs to the immunoglobulin-like family. It functions as an adhesion molecule receptor expressed on vascular endothelial cells after stimulation by inflammatory cytokines, such as IL-1β and TNF-α. It mediates the recruitment of immune cells, such as lymphocytes and monocytes, and allows their transgression through the endothelial cell wall at sites of vascular injury. VCAM1 also functions as an important component of inflammatory signalling pathways, including MAPK and NF-κB. The upregulation of VCAM1 expression has been linked to inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Sequence variation in this gene associated with stroke events, as well as cerebral but also systemic vasculopathy risk in sickle cell disease patients.

Synonyms: CD106 , INCAM-100


Sequence Viewer

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Publications / Origin

  1. Taylor JG, Tang DC, Savage SA, Leitman SF, Heller SI, Serjeant GR, Rodgers GP, Chanock SJ, Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease., Blood , 100(13), 4303-9, 2002 PubMed
  2. Kutlar A, Sickle cell disease: a multigenic perspective of a single gene disorder., Hemoglobin , 31(2), 209-24, 2007 PubMed
  3. Silva M, Vargas S, Coelho A, Ferreira E, Mendonça J, Vieira L, Maia R, Dias A, Ferreira T, Morais A, Soares IM, Lavinha J, Silva R, Kjöllerström P, Faustino P, Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry children with sickle cell anemia., Blood Cells Mol Dis, 83(0), 102436, 2020 PubMed
  4. Silva M, Coelho A, Vargas S, Faustino P, VCAM1, HMOX1 and NOS3 differential endothelial expression may impact sickle cell anemia vasculopathy., Blood Cells Mol Dis, 93(0), 102639, 2022 PubMed
Created on 2016-04-27 12:57:54, Last reviewed on 2022-03-23 17:12:15 (Show full history)

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