GeneID: 102



Names

Common Name: BMPR1A Type: Gene
Chromosome: 10 (NC_000010.11) Locus: NG_009362.1 (BMPR1A)
HUGO Symbol: BMPR1A Full Name: bone morphogenetic protein receptor type 1A
Exons: 13 Introns: 12

Description:
BMPR1A is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The BMPs are signalling molecules that belong to the transforming growth factor β (TGFβ) family of proteins and participate in several processes including cell growth, development, morphogenesis, apoptosis and immune responses. BMPs transduce their signal through the formation of heteromeric complexes with type-I and type-II receptors, which in turn activate downstream transcriptional regulators called SMADs. BMPR1A is a type-I receptor. Type-II receptors bind ligands but they require their respective type-I receptors for signalling. Polymorphisms in this gene associated with bacteremia in sickle cell patients.

Synonyms: ALK3 , SKR5 , CD292 , ACVRLK3

Comments:
N/A

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Publications / Origin

  1. Adewoye AH, Nolan VG, Ma Q, Baldwin C, Wyszynski DF, Farrell JJ, Farrer LA, Steinberg MH, Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia., Clin. Infect. Dis. , 43(5), 593-8, 2006 PubMed
  2. Miyazono K, Kamiya Y, Morikawa M, Bone morphogenetic protein receptors and signal transduction., J. Biochem. , 147(1), 35-51, 2010 PubMed
Created on 2016-04-27 11:19:24, Last reviewed on (Show full history)


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